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- B9bbfc1263ee63135a01c4731d95989aa NCIT_P378 "NCI" @default.
- B9bbfc1263ee63135a01c4731d95989aa type Axiom @default.
- B9bbfc1263ee63135a01c4731d95989aa annotatedProperty IAO_0000115 @default.
- B9bbfc1263ee63135a01c4731d95989aa annotatedSource NCIT_C62502 @default.
- B9bbfc1263ee63135a01c4731d95989aa annotatedTarget "An orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, AZD1152-HQPA specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types." @default.