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- B9bccc7f13c0982c5e273c8106d63e6f4 NCIT_P378 "NCI" @default.
- B9bccc7f13c0982c5e273c8106d63e6f4 type Axiom @default.
- B9bccc7f13c0982c5e273c8106d63e6f4 annotatedProperty IAO_0000115 @default.
- B9bccc7f13c0982c5e273c8106d63e6f4 annotatedSource NCIT_C488 @default.
- B9bccc7f13c0982c5e273c8106d63e6f4 annotatedTarget "The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues." @default.