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- B9bcf7e16fadbc2ed02396e0b4f3e7d1f NCIT_P378 "NCI" @default.
- B9bcf7e16fadbc2ed02396e0b4f3e7d1f type Axiom @default.
- B9bcf7e16fadbc2ed02396e0b4f3e7d1f annotatedProperty IAO_0000115 @default.
- B9bcf7e16fadbc2ed02396e0b4f3e7d1f annotatedSource NCIT_C48013 @default.
- B9bcf7e16fadbc2ed02396e0b4f3e7d1f annotatedTarget "The edisylate salt form of prochlorperazine, a derivative of phenothiazine with antipsychotic and antiemetic properties. Prochlorperazine edisylate blocks postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, including hallucinations and delusions. Prochlorperazine edisylate appears to exert its antiemetic activity by blocking the dopamine and histamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting." @default.