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- B9be7d3fc477ec67db28fdd83b7ea23e2 NCIT_P378 "NCI" @default.
- B9be7d3fc477ec67db28fdd83b7ea23e2 type Axiom @default.
- B9be7d3fc477ec67db28fdd83b7ea23e2 annotatedProperty IAO_0000115 @default.
- B9be7d3fc477ec67db28fdd83b7ea23e2 annotatedSource NCIT_C187044 @default.
- B9be7d3fc477ec67db28fdd83b7ea23e2 annotatedTarget "The dihydrochloride salt form of NRC-2694, an orally bioavailable, small-molecule inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, EGFR inhibitor NRC-2694 binds to and inhibits EGFR, which prevents EGFR-mediated signaling and leads to cell death in EGFR-expressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.