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- B9cd3721a6c1545875f8bf7c7a8445dff NCIT_P378 "NCI" @default.
- B9cd3721a6c1545875f8bf7c7a8445dff type Axiom @default.
- B9cd3721a6c1545875f8bf7c7a8445dff annotatedProperty IAO_0000115 @default.
- B9cd3721a6c1545875f8bf7c7a8445dff annotatedSource NCIT_C16479 @default.
- B9cd3721a6c1545875f8bf7c7a8445dff annotatedTarget "Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/Thr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homo- or heterodimeric regulatory subunits associated with two catalytic subunits. cAMP causes dissociation of inactive holoenzyme into a cAMP-bound dimer of regulatory subunits and two free monomeric catalytic subunits that phosphorylate many cytoplasmic and nuclear substrates. In human, regulatory PRKAR1A, PRKAR1B, PRKAR2A, and PRKAR2B subunits and catalytic PRKACA, PRKACB, and PRKACG subunits have been identified. (NCI)" @default.