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- B9cf24b6fbd9c7d72a30e590af436d535 NCIT_P378 "NCI" @default.
- B9cf24b6fbd9c7d72a30e590af436d535 type Axiom @default.
- B9cf24b6fbd9c7d72a30e590af436d535 annotatedProperty IAO_0000115 @default.
- B9cf24b6fbd9c7d72a30e590af436d535 annotatedSource NCIT_C189822 @default.
- B9cf24b6fbd9c7d72a30e590af436d535 annotatedTarget "A bispecific antibody directed against both the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/CD3 bispecific antibody QLS31904 binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation." @default.