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- B9d705b6c72fdfe250c50dac57bc9289c NCIT_P378 "NCI" @default.
- B9d705b6c72fdfe250c50dac57bc9289c type Axiom @default.
- B9d705b6c72fdfe250c50dac57bc9289c annotatedProperty IAO_0000115 @default.
- B9d705b6c72fdfe250c50dac57bc9289c annotatedSource NCIT_C61737 @default.
- B9d705b6c72fdfe250c50dac57bc9289c annotatedTarget "A quinazoline with antihypertensive and antineoplastic properties. Doxazosin is an alpha-adrenergic antagonist that selectively inhibits alpha-1 adrenergic receptors. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia. Furthermore, doxazosin induces apoptosis in prostate cancer cells mediated through inhibition of protein kinase B (PKB)/Akt-signaling death receptor regulatory pathway." @default.