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- B9d82f4ad6c78f65b22969c83b390329e NCIT_P378 "NCI" @default.
- B9d82f4ad6c78f65b22969c83b390329e type Axiom @default.
- B9d82f4ad6c78f65b22969c83b390329e annotatedProperty IAO_0000115 @default.
- B9d82f4ad6c78f65b22969c83b390329e annotatedSource NCIT_C175088 @default.
- B9d82f4ad6c78f65b22969c83b390329e annotatedTarget "The phosphate salt form of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Upon administration, infigratinib selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of angiogenesis and cell proliferation, and the induction of cell death in tumors with activating FGFR amplifications, mutations, or fusions. FGFRs are a family of receptor tyrosine kinases that are involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival. Activating FGFR amplifications, mutations, or fusions occur in various cancer cell types." @default.