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- B9db95efde43ee09d8fb83f2c25643e47 NCIT_P378 "NCI" @default.
- B9db95efde43ee09d8fb83f2c25643e47 type Axiom @default.
- B9db95efde43ee09d8fb83f2c25643e47 annotatedProperty IAO_0000115 @default.
- B9db95efde43ee09d8fb83f2c25643e47 annotatedSource NCIT_C1863 @default.
- B9db95efde43ee09d8fb83f2c25643e47 annotatedTarget "A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation." @default.