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- B9dd727babe545dbe93ec1f08babb3014 NCIT_P378 "NCI" @default.
- B9dd727babe545dbe93ec1f08babb3014 type Axiom @default.
- B9dd727babe545dbe93ec1f08babb3014 annotatedProperty IAO_0000115 @default.
- B9dd727babe545dbe93ec1f08babb3014 annotatedSource NCIT_C152489 @default.
- B9dd727babe545dbe93ec1f08babb3014 annotatedTarget "The succinate salt form of tafenoquine, an orally bioavailable 8-aminoquinoline derivative, with antimalarial activity. Although the mechanism is not completely understood, upon administration, tafenoquine inhibits the parasitic enzyme heme polymerase in the blood stages of the parasites. This inhibits the conversion of the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Tafenoquine is active against all the stages of Plasmodium species and is also active against the pre-erythrocytic liver stages of the parasites. This prevents the development of the erythrocytic forms of the parasite which are responsible for relapses in P. vivax malaria." @default.