Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B9e20fd3b405e33340b15314a21d33d25> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B9e20fd3b405e33340b15314a21d33d25 NCIT_P378 "NCI" @default.
- B9e20fd3b405e33340b15314a21d33d25 type Axiom @default.
- B9e20fd3b405e33340b15314a21d33d25 annotatedProperty IAO_0000115 @default.
- B9e20fd3b405e33340b15314a21d33d25 annotatedSource NCIT_C1886 @default.
- B9e20fd3b405e33340b15314a21d33d25 annotatedTarget "The hydrochloride salt form of afeletecan, a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood." @default.