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- B9e33463e31c3e2aff97f288fe259f3cd NCIT_P378 "NCI" @default.
- B9e33463e31c3e2aff97f288fe259f3cd type Axiom @default.
- B9e33463e31c3e2aff97f288fe259f3cd annotatedProperty IAO_0000115 @default.
- B9e33463e31c3e2aff97f288fe259f3cd annotatedSource NCIT_C180535 @default.
- B9e33463e31c3e2aff97f288fe259f3cd annotatedTarget "An orally available selective inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, alflutinib specifically binds to and inhibits the tyrosine kinase activity of EGFR T790M, a secondarily acquired resistance mutation. This prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Compared to some other EGFR inhibitors, alflutinib may have therapeutic benefits in tumors with T790M-mediated drug resistance." @default.