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- B9e69b334a7bc33b775d428a825c379a5 NCIT_P378 "NCI" @default.
- B9e69b334a7bc33b775d428a825c379a5 type Axiom @default.
- B9e69b334a7bc33b775d428a825c379a5 annotatedProperty IAO_0000115 @default.
- B9e69b334a7bc33b775d428a825c379a5 annotatedSource NCIT_C190744 @default.
- B9e69b334a7bc33b775d428a825c379a5 annotatedTarget "The hydrochloride salt form of lirafugratinib, an orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival." @default.