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- B9ecc3c5f457f90c0e57444fa36592d77 NCIT_P378 "NCI" @default.
- B9ecc3c5f457f90c0e57444fa36592d77 type Axiom @default.
- B9ecc3c5f457f90c0e57444fa36592d77 annotatedProperty IAO_0000115 @default.
- B9ecc3c5f457f90c0e57444fa36592d77 annotatedSource NCIT_C76219 @default.
- B9ecc3c5f457f90c0e57444fa36592d77 annotatedTarget "The indanyl ester of carbenicillin, a broad-spectrum, semisynthetic penicillin derivative with antibacterial activity. Following absorption, carbenicillin indanyl is rapidly hydrolyzed to the active carbenicillin, which binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to a weakening of the bacterial cell wall, eventually causing bacterial cell lysis." @default.