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- B9ed2531d3ef45d86156c5419df893bbb NCIT_P378 "NCI" @default.
- B9ed2531d3ef45d86156c5419df893bbb type Axiom @default.
- B9ed2531d3ef45d86156c5419df893bbb annotatedProperty IAO_0000115 @default.
- B9ed2531d3ef45d86156c5419df893bbb annotatedSource NCIT_C49185 @default.
- B9ed2531d3ef45d86156c5419df893bbb annotatedTarget "Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue." @default.