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- B9f2919b435a061675eabf9f92a71294e NCIT_P378 "NCI" @default.
- B9f2919b435a061675eabf9f92a71294e type Axiom @default.
- B9f2919b435a061675eabf9f92a71294e annotatedProperty IAO_0000115 @default.
- B9f2919b435a061675eabf9f92a71294e annotatedSource NCIT_C62065 @default.
- B9f2919b435a061675eabf9f92a71294e annotatedTarget "A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen." @default.