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- Ba00619cc0ce5c985535525c25fdf3eba NCIT_P378 "NCI" @default.
- Ba00619cc0ce5c985535525c25fdf3eba type Axiom @default.
- Ba00619cc0ce5c985535525c25fdf3eba annotatedProperty IAO_0000115 @default.
- Ba00619cc0ce5c985535525c25fdf3eba annotatedSource NCIT_C29263 @default.
- Ba00619cc0ce5c985535525c25fdf3eba annotatedTarget "The lactate salt form of milrinone, a cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle." @default.