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- Ba023eee459673c21c505c0330f8e78f6 NCIT_P378 "NCI" @default.
- Ba023eee459673c21c505c0330f8e78f6 type Axiom @default.
- Ba023eee459673c21c505c0330f8e78f6 annotatedProperty IAO_0000115 @default.
- Ba023eee459673c21c505c0330f8e78f6 annotatedSource NCIT_C61527 @default.
- Ba023eee459673c21c505c0330f8e78f6 annotatedTarget "A synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Atorvastatin also increases the number of LDL receptors on hepatic cell surfaces to enhance uptake and catabolism of LDL and reduces LDL production and the number of LDL particles. This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)" @default.