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- Ba0433d1fcb98dc59fcc13bea61dcb48a NCIT_P378 "NCI" @default.
- Ba0433d1fcb98dc59fcc13bea61dcb48a type Axiom @default.
- Ba0433d1fcb98dc59fcc13bea61dcb48a annotatedProperty IAO_0000115 @default.
- Ba0433d1fcb98dc59fcc13bea61dcb48a annotatedSource NCIT_C38142 @default.
- Ba0433d1fcb98dc59fcc13bea61dcb48a annotatedTarget "An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction." @default.