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- Ba0b38081c5e8446f13c0397eb27e6602 NCIT_P378 "NCI" @default.
- Ba0b38081c5e8446f13c0397eb27e6602 type Axiom @default.
- Ba0b38081c5e8446f13c0397eb27e6602 annotatedProperty IAO_0000115 @default.
- Ba0b38081c5e8446f13c0397eb27e6602 annotatedSource NCIT_C201072 @default.
- Ba0b38081c5e8446f13c0397eb27e6602 annotatedTarget "A trispecific T-cell engaging (TCE) antibody directed against two different epitopes of the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/DLL3/CD3 trispecific antibody ZG006 binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation." @default.