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- Ba0c2e72b4a586976f3bce518ca9f7058 NCIT_P378 "NCI" @default.
- Ba0c2e72b4a586976f3bce518ca9f7058 type Axiom @default.
- Ba0c2e72b4a586976f3bce518ca9f7058 annotatedProperty IAO_0000115 @default.
- Ba0c2e72b4a586976f3bce518ca9f7058 annotatedSource NCIT_C1044 @default.
- Ba0c2e72b4a586976f3bce518ca9f7058 annotatedTarget "The hydrochloride salt of the nonsteroidal aromatase inhibitor fadrozole with potential antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, the final step in estrogen biosynthesis; the reduction in estrogen levels may inhibit growth in estrogen-dependent cancers. Aromatase, a member of the cytochrome P-450 superfamily, is found in many tissues; overexpression has been linked to the development of preneoplastic and neoplastic changes in breast tissue." @default.