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- Ba0f362b5ec4cb4e20e0b0af1dbbdd48d NCIT_P378 "NCI" @default.
- Ba0f362b5ec4cb4e20e0b0af1dbbdd48d type Axiom @default.
- Ba0f362b5ec4cb4e20e0b0af1dbbdd48d annotatedProperty IAO_0000115 @default.
- Ba0f362b5ec4cb4e20e0b0af1dbbdd48d annotatedSource NCIT_C61311 @default.
- Ba0f362b5ec4cb4e20e0b0af1dbbdd48d annotatedTarget "An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms." @default.