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- Ba105fd2f2813673abe549c38a9927fe7 NCIT_P378 "NCI" @default.
- Ba105fd2f2813673abe549c38a9927fe7 type Axiom @default.
- Ba105fd2f2813673abe549c38a9927fe7 annotatedProperty IAO_0000115 @default.
- Ba105fd2f2813673abe549c38a9927fe7 annotatedSource NCIT_C38210 @default.
- Ba105fd2f2813673abe549c38a9927fe7 annotatedTarget "Administration of the drug in the epidural space, usually at the lumbar level of the spine. The drug must initially cross the dura mater before exerting its effect on the nervous system components. The drug is also subject to uptake into the rich epidural plexus of veins. Uptake and distribution after epidural administration resembles that seen after intramuscular injection. The portion of drug that is not taken into the vascular compartment is available to cross the dura. Hydrophilicity is a major component in the pharmacokinetics of drug transfer into the subdural space." @default.