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- Ba12cb8d70c3e0a6e8cff1d524b0e47a8 NCIT_P378 "NCI" @default.
- Ba12cb8d70c3e0a6e8cff1d524b0e47a8 type Axiom @default.
- Ba12cb8d70c3e0a6e8cff1d524b0e47a8 annotatedProperty IAO_0000115 @default.
- Ba12cb8d70c3e0a6e8cff1d524b0e47a8 annotatedSource NCIT_C620 @default.
- Ba12cb8d70c3e0a6e8cff1d524b0e47a8 annotatedTarget "A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation." @default.