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- Ba1b8751e4a6f6c84b8cf09533681cf11 NCIT_P378 "NCI" @default.
- Ba1b8751e4a6f6c84b8cf09533681cf11 type Axiom @default.
- Ba1b8751e4a6f6c84b8cf09533681cf11 annotatedProperty IAO_0000115 @default.
- Ba1b8751e4a6f6c84b8cf09533681cf11 annotatedSource NCIT_C62046 @default.
- Ba1b8751e4a6f6c84b8cf09533681cf11 annotatedTarget "A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting." @default.