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- Ba1cddca15111a85442b4f965a76e315f NCIT_P378 "NCI" @default.
- Ba1cddca15111a85442b4f965a76e315f type Axiom @default.
- Ba1cddca15111a85442b4f965a76e315f annotatedProperty IAO_0000115 @default.
- Ba1cddca15111a85442b4f965a76e315f annotatedSource NCIT_C1214 @default.
- Ba1cddca15111a85442b4f965a76e315f annotatedTarget "A naturally occurring capsaicin analog found in the latex of the cactus Euphorbia resinifera with analgesic activity. Resiniferatoxin (RTX) binds to and activates the transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the plasma membrane of primary afferent sensory neurons. This increases the permeability to cations, and leads to an influx of calcium and sodium ions. This results in membrane depolarization, causing an irritant effect, followed by desensitization of the sensory neurons thereby inhibiting signal conduction in afferent pain pathways and causing analgesia. TRPV1, a member of the transient receptor potential channel (TRP) superfamily, is a heat- and chemo-sensitive calcium/sodium ion channel that is selectively expressed in a subpopulation of pain-sensing primary afferent neurons." @default.