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- Ba1f6db21aaaebf1799a076be2795e709 NCIT_P378 "NCI" @default.
- Ba1f6db21aaaebf1799a076be2795e709 type Axiom @default.
- Ba1f6db21aaaebf1799a076be2795e709 annotatedProperty IAO_0000115 @default.
- Ba1f6db21aaaebf1799a076be2795e709 annotatedSource NCIT_C85445 @default.
- Ba1f6db21aaaebf1799a076be2795e709 annotatedTarget "A cancer vaccine consisting of autologous dendritic cells (DCs) loaded with CD133-positive autologous brain tumor stem cells (BTSCs) -derived mRNA with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, autologous CD133-positive BTSC mRNA-pulsed autologous dendritic cell vaccine may elicit a cytotoxic T-lymphocyte (CTL) response against the CD133-positive BTSCs from which the autologous tumor mRNA is derived. CD133, a tumor-associated antigen (TAA) and neural stem cell marker, has been found on a specific subset of glioblastoma multiforme (GBM) stem cells; its presence has been correlated with resistance to conventional chemotherapy and radiotherapy." @default.