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- Ba20abc18d98f6456a6228d4587a7bfaa NCIT_P378 "NCI" @default.
- Ba20abc18d98f6456a6228d4587a7bfaa type Axiom @default.
- Ba20abc18d98f6456a6228d4587a7bfaa annotatedProperty IAO_0000115 @default.
- Ba20abc18d98f6456a6228d4587a7bfaa annotatedSource NCIT_C101792 @default.
- Ba20abc18d98f6456a6228d4587a7bfaa annotatedTarget "A formulation of the 6-omega fatty acid derivative 2'-linoleyl carbonate (LOC) conjugated to paclitaxel, a taxane compound extracted from the Pacific yew tree Taxus brevifolia, with potential antineoplastic activity. Paclitaxel binds to and stabilizes tubulin, thereby interfering with the dynamics of microtubule assembly/disassembly and resulting in the inhibition of cell division. LOC enhances the uptake of paclitaxel by tumor cells, thereby concentrating this agent in tumor cells compared to normal cells, and may decrease its toxicity profile; fatty acids serve as energy sources and biochemical precursors for the fast growing tumor cells." @default.