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- Ba20e2916d121e50c9daced6b7f335e15 NCIT_P378 "NCI" @default.
- Ba20e2916d121e50c9daced6b7f335e15 type Axiom @default.
- Ba20e2916d121e50c9daced6b7f335e15 annotatedProperty IAO_0000115 @default.
- Ba20e2916d121e50c9daced6b7f335e15 annotatedSource NCIT_C193472 @default.
- Ba20e2916d121e50c9daced6b7f335e15 annotatedTarget "An attenuated oncolytic influenza A virus, with hemagglutinin and neuraminidase genes of influenza virus strain A/California/07/2009 codon-pair deoptimized, with potential oncolytic activity. Upon intratumoral administration, oncolytic influenza A virus selectively targets and replicates in cancer cells without being able to infect and replicate in normal, healthy cells. This induces selective oncolytic virus-mediated cytotoxicity in cancer cells, which leads to cancer cell lysis. Following the lysis of infected cells, the replicated virus is released and can infect adjacent tumor cells, which both induces further tumor cell oncolysis and may activate the immune system to exert an anti-tumor immune response against the tumor cells." @default.