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- Ba298fe78f30bc06eb6380a3ae069bb31 NCIT_P378 "NCI" @default.
- Ba298fe78f30bc06eb6380a3ae069bb31 type Axiom @default.
- Ba298fe78f30bc06eb6380a3ae069bb31 annotatedProperty IAO_0000115 @default.
- Ba298fe78f30bc06eb6380a3ae069bb31 annotatedSource NCIT_C60773 @default.
- Ba298fe78f30bc06eb6380a3ae069bb31 annotatedTarget "An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area." @default.