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- Ba2fe4f19e88c2cd55e520042170efd36 NCIT_P378 "NCI" @default.
- Ba2fe4f19e88c2cd55e520042170efd36 type Axiom @default.
- Ba2fe4f19e88c2cd55e520042170efd36 annotatedProperty IAO_0000115 @default.
- Ba2fe4f19e88c2cd55e520042170efd36 annotatedSource NCIT_C47622 @default.
- Ba2fe4f19e88c2cd55e520042170efd36 annotatedTarget "The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes." @default.