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- Ba33cae63861761c8abecfeb5462e10b4 NCIT_P378 "NCI" @default.
- Ba33cae63861761c8abecfeb5462e10b4 type Axiom @default.
- Ba33cae63861761c8abecfeb5462e10b4 annotatedProperty IAO_0000115 @default.
- Ba33cae63861761c8abecfeb5462e10b4 annotatedSource NCIT_C845 @default.
- Ba33cae63861761c8abecfeb5462e10b4 annotatedTarget "A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)" @default.