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- Ba3c8ebf16bad5e365773b27702cc7308 NCIT_P378 "NCI" @default.
- Ba3c8ebf16bad5e365773b27702cc7308 type Axiom @default.
- Ba3c8ebf16bad5e365773b27702cc7308 annotatedProperty IAO_0000115 @default.
- Ba3c8ebf16bad5e365773b27702cc7308 annotatedSource NCIT_C61072 @default.
- Ba3c8ebf16bad5e365773b27702cc7308 annotatedTarget "A fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum." @default.