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- Ba4465a1318c8661cc0abcd930fc547f9 NCIT_P378 "NCI" @default.
- Ba4465a1318c8661cc0abcd930fc547f9 type Axiom @default.
- Ba4465a1318c8661cc0abcd930fc547f9 annotatedProperty IAO_0000115 @default.
- Ba4465a1318c8661cc0abcd930fc547f9 annotatedSource NCIT_C186746 @default.
- Ba4465a1318c8661cc0abcd930fc547f9 annotatedTarget "A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k) monoclonal antibody directed against the cell surface glycoprotein CD38, conjugated to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the radioisotope indium In 111, with potential use as an imaging agent. Upon administration, the monoclonal antibody moiety of indium In 111-DOTA-daratumumab specifically targets and binds to cell surface antigen CD38. Upon binding and gamma scintigraphy, CD38-expressing tumor cells can be visualized, and the binding and biodistribution of daratumumab can be assessed. CD38, a cell surface glycoprotein, is expressed on various hematopoietic cells and is overexpressed on multiple myeloma (MM) cells." @default.