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- Ba48ccef2c204e828cdd5af009a2464c1 NCIT_P378 "NCI" @default.
- Ba48ccef2c204e828cdd5af009a2464c1 type Axiom @default.
- Ba48ccef2c204e828cdd5af009a2464c1 annotatedProperty IAO_0000115 @default.
- Ba48ccef2c204e828cdd5af009a2464c1 annotatedSource NCIT_C1527 @default.
- Ba48ccef2c204e828cdd5af009a2464c1 annotatedTarget "A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis." @default.