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- Ba4d76a22548094ac778f39fac49857d7 NCIT_P378 "NCI" @default.
- Ba4d76a22548094ac778f39fac49857d7 type Axiom @default.
- Ba4d76a22548094ac778f39fac49857d7 annotatedProperty IAO_0000115 @default.
- Ba4d76a22548094ac778f39fac49857d7 annotatedSource NCIT_C61499 @default.
- Ba4d76a22548094ac778f39fac49857d7 annotatedTarget "A nitric oxide (NO) donating derivative of acetylsalicylic acid with anti-inflammatory, analgesic, antipyretic, antithrombotic, gastroprotective and potential antitumor activities. The acetylsalicylic acid derivative moiety of this agent inhibits the activities of cyclooxygenase (COX) I and II, preventing the formation of prostaglandins and thromboxanes. A reduction in prostaglandin synthesis accounts for this agent's anti-inflammatory, anti-pyretic and analgesic activities; a reduction in thromboxane A2 synthesis results in an irreversible inhibition of platelet aggregation. NO donation by this agent, after cleavage from the acetylsalicylic acid derivative in vivo, may protect the gastric mucosa against the damaging effects of the aspirin derivative by modulating prostaglandins. In tumor cells, the NO donating moiety may block the cell cycle in the G1 and G2 phases and may induce apoptosis through caspase-mediated mechanisms." @default.