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- Ba58ed1c1f4226bcbbefb2b756dfff12f NCIT_P378 "NCI" @default.
- Ba58ed1c1f4226bcbbefb2b756dfff12f type Axiom @default.
- Ba58ed1c1f4226bcbbefb2b756dfff12f annotatedProperty IAO_0000115 @default.
- Ba58ed1c1f4226bcbbefb2b756dfff12f annotatedSource NCIT_C66948 @default.
- Ba58ed1c1f4226bcbbefb2b756dfff12f annotatedTarget "A cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins." @default.