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- Ba5a0ef87b47dd59112bae375e11be907 NCIT_P378 "NCI" @default.
- Ba5a0ef87b47dd59112bae375e11be907 type Axiom @default.
- Ba5a0ef87b47dd59112bae375e11be907 annotatedProperty IAO_0000115 @default.
- Ba5a0ef87b47dd59112bae375e11be907 annotatedSource NCIT_C47668 @default.
- Ba5a0ef87b47dd59112bae375e11be907 annotatedTarget "A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects." @default.