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- Ba5cf9941b204e4c936d9421e7a9bcdad NCIT_P378 "BIOCARTA" @default.
- Ba5cf9941b204e4c936d9421e7a9bcdad type Axiom @default.
- Ba5cf9941b204e4c936d9421e7a9bcdad annotatedProperty NCIT_P325 @default.
- Ba5cf9941b204e4c936d9421e7a9bcdad annotatedSource NCIT_C39054 @default.
- Ba5cf9941b204e4c936d9421e7a9bcdad annotatedTarget "Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression, leading to cell shape changes during cell spreading or migration. Epithelial cells respond to extracellular matrix (ECM) causing integrin-mediated FAK phosphorylation; this, in turn, phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to signal amplification. FAK also binds PI-3 kinase and acts upstream in the MAP kinase pathway. When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked. Src phosphorylates p190RhoGAP, inactivating its GAP function and allowing RhoGTP to stay active longer, promoting further signal amplification. Activated RhoGTP binds to downstream kinases such as Rho-associated coiled coil-containing protein kinase (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other signal transduction events. (This definition may be outdated - see the DesignNote.)" @default.