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- Ba5da1b46c17cb81a3dbe60e3bc113ca8 hasDbXref "ISBN:8793237073" @default.
- Ba5da1b46c17cb81a3dbe60e3bc113ca8 hasDbXref "PMID:20235044" @default.
- Ba5da1b46c17cb81a3dbe60e3bc113ca8 type Axiom @default.
- Ba5da1b46c17cb81a3dbe60e3bc113ca8 annotatedProperty IAO_0000115 @default.
- Ba5da1b46c17cb81a3dbe60e3bc113ca8 annotatedSource MP_0013779 @default.
- Ba5da1b46c17cb81a3dbe60e3bc113ca8 annotatedTarget "any functional anomaly of the outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane; basal cells (aka myoepithelial cells or MECs) are specialized epithelial cells that express smooth muscle-specific contractile and cytoskeletal properties; during lactation, MECs contract in response to oxytocin to generate the contractile force required for milk ejection; MECs are involved in all developmental stages of mammary gland morphogenesis, modulating proliferation and differentiation of luminal cells; they take part in the formation of extracellular matrix, synthesizing its components and secreting proteinases and their inhibitors; in addition, MECs are regarded as natural cancer suppressors: they secrete suppressor proteins limiting cancer growth, invasiveness, and neoangiogenesis; MECs are markedly resistant to malignant transformation and they are able to suppress the transformation of neighboring luminal cells" @default.