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- Ba62c102b70f052b49fdc20d5cd451d40 NCIT_P378 "NCI" @default.
- Ba62c102b70f052b49fdc20d5cd451d40 type Axiom @default.
- Ba62c102b70f052b49fdc20d5cd451d40 annotatedProperty IAO_0000115 @default.
- Ba62c102b70f052b49fdc20d5cd451d40 annotatedSource NCIT_C47487 @default.
- Ba62c102b70f052b49fdc20d5cd451d40 annotatedTarget "A phenylpiperidine with antidiarrheal activity and active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin hydrochloride acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibits the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects." @default.