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- Ba6352cd477a532bb7abcf2b9cf1a962b NCIT_P378 "NCI" @default.
- Ba6352cd477a532bb7abcf2b9cf1a962b type Axiom @default.
- Ba6352cd477a532bb7abcf2b9cf1a962b annotatedProperty IAO_0000115 @default.
- Ba6352cd477a532bb7abcf2b9cf1a962b annotatedSource NCIT_C104732 @default.
- Ba6352cd477a532bb7abcf2b9cf1a962b annotatedTarget "An orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers." @default.