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- Ba6359ebefafda5c9c54afa42c93232ac NCIT_P378 "NCI" @default.
- Ba6359ebefafda5c9c54afa42c93232ac type Axiom @default.
- Ba6359ebefafda5c9c54afa42c93232ac annotatedProperty IAO_0000115 @default.
- Ba6359ebefafda5c9c54afa42c93232ac annotatedSource NCIT_C190727 @default.
- Ba6359ebefafda5c9c54afa42c93232ac annotatedTarget "The mesylate salt form of leuprolide, a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, leuprolide binds to and activates the gonadotropin-releasing hormone receptor (GnRHR). The continuous stimulation of GnRHR by leuprolide results in both the desensitization of pituitary GnRHR and the inhibition of pituitary secretion of the gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH). In males, this results in a significant decline in testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.