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- Ba6ed48b78164106ce906b6e71ebc0b57 NCIT_P378 "NCI" @default.
- Ba6ed48b78164106ce906b6e71ebc0b57 type Axiom @default.
- Ba6ed48b78164106ce906b6e71ebc0b57 annotatedProperty IAO_0000115 @default.
- Ba6ed48b78164106ce906b6e71ebc0b57 annotatedSource NCIT_C1703 @default.
- Ba6ed48b78164106ce906b6e71ebc0b57 annotatedTarget "A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04)" @default.