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- Ba765350c1ba60a9c5e168b5f368f6e09 NCIT_P378 "NCI" @default.
- Ba765350c1ba60a9c5e168b5f368f6e09 type Axiom @default.
- Ba765350c1ba60a9c5e168b5f368f6e09 annotatedProperty IAO_0000115 @default.
- Ba765350c1ba60a9c5e168b5f368f6e09 annotatedSource NCIT_C76970 @default.
- Ba765350c1ba60a9c5e168b5f368f6e09 annotatedTarget "The dimaleate salt form of atiprimod, an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition of cell proliferation, induction of cell cycle arrest, and apoptosis." @default.