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- Ba774560e4b06e63f90dd1e7acee21744 NCIT_P378 "NCI" @default.
- Ba774560e4b06e63f90dd1e7acee21744 type Axiom @default.
- Ba774560e4b06e63f90dd1e7acee21744 annotatedProperty IAO_0000115 @default.
- Ba774560e4b06e63f90dd1e7acee21744 annotatedSource NCIT_C61669 @default.
- Ba774560e4b06e63f90dd1e7acee21744 annotatedTarget "A semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.