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- Ba84c98e3fb74efe6f1798001a8b95fac NCIT_P378 "NCI" @default.
- Ba84c98e3fb74efe6f1798001a8b95fac type Axiom @default.
- Ba84c98e3fb74efe6f1798001a8b95fac annotatedProperty IAO_0000115 @default.
- Ba84c98e3fb74efe6f1798001a8b95fac annotatedSource NCIT_C102875 @default.
- Ba84c98e3fb74efe6f1798001a8b95fac annotatedTarget "A formulation of nanoparticles encapsulating the hydrochloride salt form of the anthracycline antibiotic doxorubicin, with potential antitumor activity. Upon intravenous administration, doxorubicin intercalates DNA, interferes with the activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors and may circumvent the tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant tumor cells." @default.