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- Ba85ac40d40a0b76dafbc0ea47e53485a NCIT_P378 "NCI" @default.
- Ba85ac40d40a0b76dafbc0ea47e53485a type Axiom @default.
- Ba85ac40d40a0b76dafbc0ea47e53485a annotatedProperty IAO_0000115 @default.
- Ba85ac40d40a0b76dafbc0ea47e53485a annotatedSource NCIT_C107505 @default.
- Ba85ac40d40a0b76dafbc0ea47e53485a annotatedTarget "T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138) (CART-138 T cells) coupled to the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD138CAR- CD137/TCRzeta -expressing T lymphocytes directs the T-lymphocytes to syndecan-1-expressing tumor cells and induces selective toxicity in those tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of syndecan-1. Syndecan-1, a type 1 transmembrane proteoglycan and tumor associated antigen, is overexpressed in a variety of cancer cells. It plays a key role in the regulation of cell growth, differentiation, and adhesion, and its expression is correlated with poor prognosis." @default.