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- Ba868e4ca91b2f35088b5bfb4af3a0cb0 NCIT_P378 "NCI" @default.
- Ba868e4ca91b2f35088b5bfb4af3a0cb0 type Axiom @default.
- Ba868e4ca91b2f35088b5bfb4af3a0cb0 annotatedProperty IAO_0000115 @default.
- Ba868e4ca91b2f35088b5bfb4af3a0cb0 annotatedSource NCIT_C1382 @default.
- Ba868e4ca91b2f35088b5bfb4af3a0cb0 annotatedTarget "An indolocarbazole-based alkaloid and staurosporine analog isolated from Nocardiopsis and Actinomadura species, with kinase inhibiting activity. K252a inhibits a wide variety of enzymes, including, but not limited to, protein kinase A (PKA), C (PKC) and G (PKG), calcium (Ca2+)/calmodulin-dependent kinase type II (CaMKII), phosphorylase kinase (PhK), tropomyosin receptor kinase (Trk; neurotrophic tyrosine receptor kinase; NTRK), myosin light-chain kinase (MLCK; MYLK), mixed-lineage protein kinase 3 (MLK3), receptor-type tyrosine-protein kinase FLT3 (CD135; fms-like tyrosine kinase 3; fetal liver kinase-2; FLK2) and actin-regulating kinase PRK1 (PAK1). Inhibition of these kinases prevents the activation of signaling pathways in which these kinases play a key role." @default.