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- Ba869a9ba8c1f39efe6b6e5338f8e34a8 NCIT_P378 "NCI" @default.
- Ba869a9ba8c1f39efe6b6e5338f8e34a8 type Axiom @default.
- Ba869a9ba8c1f39efe6b6e5338f8e34a8 annotatedProperty IAO_0000115 @default.
- Ba869a9ba8c1f39efe6b6e5338f8e34a8 annotatedSource NCIT_C127116 @default.
- Ba869a9ba8c1f39efe6b6e5338f8e34a8 annotatedTarget "An orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon administration, dubermatinib targets and binds to AXL and prevents its activity. This blocks AXL-mediated signal transduction pathways and inhibits the epithelial-mesenchymal transition (EMT), which, in turn, inhibits tumor cell proliferation and migration. In addition, TP-0903 enhances chemo-sensitivity to certain other chemotherapeutic agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases and overexpressed by many tumor cell types, plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis." @default.